Carbapenem-resistant bacteria in an intensive care unit: prevalence and associated factors

Antimicrobial resistance is a global threat that requires different care and factors involved including unified, multidimensional approach, with greater epidemiological surveillance. The objective this study was to review the prevalence associated healthcare-related infections (HAI) caused by bacteria resistant carbapenems in adult patients admitted Intensive Care Unit (ICU). This cross-sectional accomplished through of electronic medical records microbiological tests ICU hospital southern Santa Catarina between 2010 2017. Demographic, clinical antimicrobial use data were part variables interest. A total 1,273 HAI cases included, 11.5% infection rate. mean age 60.4±18.5 years; 58.7% men. main cause hospitalization cardiac-related diseases (35.8%) median stay 31 days. Of number cases, 24% due carbapenem resistance. HAIs Escherichia coli, coagulase-negative Staphylococcus/Staphylococcus aureus Streptococcus sp. pathogens showed carbapenems. Resistance longer (p=0.014), surgical procedure (p<0.001), nasoenteral tube (p=0.048) death (p=0.003). There high rate observed increased frequency significantly over duration period.